An Israeli Occupation air strike on Syria's capital Damascus killed 15 people early Sunday morning and badly damaged a building in a district home to several state security agencies, a war monitoring group said.

Civilians, including two women, were among those killed.

The overnight strike cratered a road and wrecked the adjacent 10-story building in the city's Kafr Sousa district, which is home to senior state officials and Syrian intelligence headquarters, said the Britain-based Observatory.

A woman was also killed in the capital's Mazraa district, possibly hit when Syrian anti-aircraft munitions crashed down from the night sky, said the Observatory.

It was not immediately clear who was the intended target of the strike, which AFP correspondents reported shook the city and left a gaping hole in the street, also blowing out windows of nearby buildings.

Other missiles overnight hit a warehouse used by Iranian and Hezbollah fighters near Damascus said the Observatory, which relies on a wide network of sources inside Syria.

Syria's defense ministry overnight confirmed the Kafr Sousa attack and gave an initial death toll of five, including one soldier, and 15 wounded civilians, some in critical condition.

Shortly after midnight "the Israeli enemy carried out an aerial aggression from the direction of the occupied Golan Heights targeting several areas in Damascus and its vicinity, including residential neighborhoods", it said.

Syrian defense forces had "shot down several missiles", the ministry added in its statement.

Historic buildings near the medieval Damascus citadel were also "severely damaged", said the head of the Syrian antiquities department, Nazir Awad, who blamed "an Israeli missile".

An Israeli Occupation army's spokesperson Sunday said "Israel does not comment on reports in foreign media".